|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
|
20921572 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
|
25648279 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression, despite the fact that many included individual studies did not show this effect.
|
29102837 |
2018 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
|
27073970 |
2017 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
|
17941097 |
2008 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission.
|
27409526 |
2017 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: a replication study.
|
23481907 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three single-nucleotide polymorphisms (rs6265, rs7103411 and rs908867) were also found to modify the association between depression and promoter I methylation.
|
26285129 |
2015 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study was to examine the chronic stress × BDNF Val66Met</span> interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.
|
29734099 |
2018 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to investigate whether BDNF gene promoter methylation status and val66met polymorphism were associated with depression ascertained at two weeks and one year after stroke.
|
23399480 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
|
20016225 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings are in accordance with the previously uncovered pathway between BDNF Val66Met, resting state EEG alpha power, and depression severity.
|
23733090 |
2013 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no interaction between depression and Val66Met genotype status.
|
25188405 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
|
17632285 |
2007 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
|
21420735 |
2011 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
|
24433458 |
2014 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
|
16343697 |
2006 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
|
22033217 |
2012 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
|
28249185 |
2017 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity.
|
20346518 |
2010 |
|
Mental Depression
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes.
|
18205169 |
2008 |